Careers

Recruitment

10-1-2022, Principal / Senior Scientist / Scientist, Biologics Drug Discovery

          We are seeking a full-time, collaborative and self-motivated biologist to join us harnessing various modalities of antibody therapeutics to modulate novel and challenging therapeutic targets in Immuno-Oncology. The successful candidate will lead and/or participate in the discovery and development of antibody therapeutics from early discovery up to pre-IND stage. The successful candidate will utilize internal and externa capabilities, including various antibody discovery platforms, to develop innovative antibody therapeutics to fulfill unmet medical needs for cancer patients. 

           We sponsor H-1 visa application and offer global business travel and working opportunity. 

           If interested, please send your resume to jobs@adepttx.com


KEY RESPONSIBILITIES
 •  Discover and characterize therapeutic antibody hits, perform in vitro cellular and  biochemical assays, participate in design and evaluation of in vivo preclinical study results to nominate development candidate for IND enabling and clinic studies. 
 •  Independently design, establish and optimize in vitro cellular, immunological and biochemical assays to support identification and validation of novel targets and/or mechanism of action (MOA) studies of drug candidates for Immuno-Oncology.
 •  Timely document and maintain detailed experimental lab notebooks; appropriately analyze and interpret experimental results; prepare, review and deliver high quality scientific presentations for internal/external use.
 •  Draft and/or review technical reports/research protocols/SOPs, and scientific manuscript for patent application and/or publication.
 •  Support and manage external collaborations, including CROs, and academic laboratories.
 •  Commit to help the team achieve deliverables and meet aggressive timelines.
 •  Such other responsibilities as may be assigned from time to time.


QUALIFICATIONS
 •  Ph.D. in immunology, cell biology, molecular biology, biochemistry.

 •  Minimum 2 years of postdoctoral research or industry working experience with a strong background in immunology and/or cancer biology. 

 •  Extensive knowledge and hands-on experience of T cell, NK cell and/or myeloid cell biology, and good understanding of B cell immunology.
 •  Ability to innovate, apply and develop new tools for assay development, proposing/validating MOA.

 •  Strong scientific background and publication record with proven high levels of performance.
 •  Ability to adapt to increasing scope of responsibility, and fast paced startup biotech environment.

 •  Knowledge of industry trends and familiarity with project related  scientific literature, and ability to utilize that expertise to troubleshoot  administrative and technical issues and to prioritize tasks to meet  business needs.
 •  Proficient in basic immunobiology and/or molecular biology technical skills, including multi-color flow cytometry, culture of primary cells and  cell lines, transient/stable transfection and cell line selection,ELISA,  PCR, molecular cloning. Experience of antibody discovery, or  recombinant protein expression and purification, or GPCR  overexpressing cell line generation, or animal immunization and/or in  vivo studies is a plus.
 •  Position title and compensation will be determined by years of relevant  experiences.


BENEFITS
 •  Bonus Pay
 •  Employee Incentive Plan: Stock Option
 •  Health Insurance Benefit
 •  Retirement Plan: 401(K) or Roth 401(K), and 401(K) Matching
 •  Paid Time Off: Vacation, Sick day, Personal day
 •  Flexible Work Schedule


COMPANY BACKGORUND
       Adept Therapeutics Inc. (AdeptTx) is an innovative start-up biotech company  located at Beverly and Woburn in Great Boston area, MA, with passion and commitment  to discover and develop potentially life-changing medicines for people with unmet  medical needs. Focusing on T cells, Natural Killer (NK) cells and immune-suppressive  myeloid cells, we leverage multiple advanced antibody technologies to discover fully human or humanized antibody therapeutics to enhance anti-tumor immunity. We are  establishing and optimizing two unique platforms including immune cell engager  bispecific antibodies and multi-functional tri-specific antibodies, which change tumor  microenvironment (TME) to boost immune responses against cancer cells through 1)  recruiting and activating effector immune cells and 2) modulating immune-suppressive TME to support tumor killing effector cell function. Our expertise in GPCR antibody  discovery and development enables us to reach for the “high-hanging fruits”, the most  challenging targets for antibody therapeutics discovery. Our broad product portfolio  focuses on both hematological malignancies, such as cutaneous lymphoma, and solid  tumors including triple negative breast cancer, ovarian, colon, kidney, renal and  pancreatic cancers etc.

        Adept Therapeutics, Inc. is committed to providing equal employment opportunities to  all employees and applicants for employment without regard to race, color, religion, sex,  sexual orientation, national origin, marital, domestic partnership or civil union status,  age, disability, genetic information, status as a veteran or as a member of the military or  status in any group protected by applicable federal or state laws.


10-1-2022, Scientist/Associate Scientist/Research Associate, Antibody Discovery

        We are seeking highly organized, collaborative and self-motivated Scientist or Associate Scientist or Research Associate to join us harnessing various modalities of antibody therapeutics to modulate novel and challenging therapeutic targets in Immuno Oncology. The successful candidate will be responsible for wet lab work for the discovery of antibody therapeutics from early discovery up to pre-IND stage. The successful candidate will utilize molecular biology and immunology knowledge and skills to help discover and develop innovative antibody therapeutics to fulfill unmet medical needs for cancer patients. The successful candidate should be flexible, ready to troubleshoot, and have excellent communication and teamwork skill to ensure smooth co-ordination and completion of assigned tasks and activities. Full training will be provided.


        We sponsor H-1 visa application and offer global business travel and working opportunity.
        If interested, please send your resume to jobs@adepttx.com


KEY RESPONSIBILITIES
 •  Perform molecular, cellular and immunological experiments, including but not limited to PCR, electrophoresis, plasmid construction, western blot, protein engineering, protein expression and purification, cell culture of cell lines, transient and stable transfection, isolation, phenotyping and culture of human, monkey and/or rodent primary cells.
 •  Learn and optimize company platform technology, including but not limited to high throughput single B cell cloning/culture, 96-well transfection, production /purification and quantification of antibodies/biologics; commitment to simultaneously handle 4-8 96-well and/or 24-well plates is required.
 •  QC of purified proteins using standard techniques, such as SDS-PAGE and SEC-HPLC.
 •  Characterization of antibodies (transfection supernatant or purified) by employing flow cytometry, ELISA, ADCC, CDC, ADCP, and/or other biochemical or cell-based functional assay(s).
 •  Timely document and maintain detailed experimental laboratory notebooks; generate and analyze appropriately high-quality experimental results for the preparation presentation for internal/external use.
 •  Draft and/or review technical reports/research protocols/SOPs, and scientific manuscriptfor patent application and/or publication.
 •  Support external collaborations, including CROs and academic laboratories.
 •  Work at a fast pace and adapt to changing priorities to meet program and team needs.

 •  Such other responsibilities as may be assigned from time to time.



QUALIFICATIONS
 •  Ph.D. or M.S. or B.S. in molecular biology, cell biology, immunology, biochemistry, biomedical engineering.
 •  Ph.D. with 2+ years, M.S. with 4+ year, B.S. with 5+ years of academia or industry working experience.
 •  Proficient in molecular biology and/or basic immunobiology skills, including PCR, DNA and protein electrophoresis, molecular cloning, culture of primary cells and cell lines, transient/stable transfection and cell line generation, flow cytometry, ELISA.
 •  Experience of antibody discovery, GPCR overexpressing cell line generation, or cell-based potency assay, or animal immunization, and/or in vivo studies is a plus.
 •  Track record of demonstrating analytical skills, bench skills and problem-solving skills.
 •  Must be a team player and collaborator in a fast-growing environment.
 •  Excellent verbal and written communication and interpersonal skills.

 •  Position title and compensation will be determined by years of relevant experiences.




BENEFITS
 •  Bonus Pay
 •  Employee Incentive Plan: Stock Option
 •  Health Insurance Benefit
 •  Retirement Plan: 401(K) or Roth 401(K), 401(K) Matching
 •  Paid Time Off: Vacation, Sick day, Personal day
 •  Flexible Work Schedule



COMPANY BACKGORUND
       Adept Therapeutics Inc. (AdeptTx) is an innovative start-up biotech company located at Woburn and Beverly in Great Boston area, MA, with passion for following the science and committing to find potentially life-changing medicines for people with unmet medical needs. Focusing on T cells, Natural Killer (NK)cells and immune-suppressive myeloid cells, we leverage multiple advanced antibody technologies to discover full human or humanized antibody therapeutics to enhance anti-tumor immunity. We are establishing and optimizing two unique platforms including immune cell engager bispecific antibodies and multi-functional tri-specific antibodies, which change tumor microenvironment (TME) to boost immune responses against cancer cells through 1) recruiting and activating effector immune cells and 2) modulating immune-suppressive TME to support tumor killing effector cell function. Our expertise in GPCR antibody discovery and development enables us to reach for the “high-hanging fruits”, the most challenging targets for therapeutic antibody discovery. Our broad product portfolio focuses on both hematological malignancies, such as cutaneous lymphoma,and solid tumors including triple negative breast cancer, ovarian, colon, kidney, renal and pancreatic cancers etc.



      Adept Therapeutics, Inc. is committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, national origin, marital, domestic partnership or civil union status, age, disability, genetic information, status as a veteran or as a member of the military or status in any group protected by applicable federal or state laws.


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